Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1005)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0875290	0.0998201	0.3904797
Weighted median	23	-0.0091394	0.0570287	0.8726764
Inverse variance weighted	23	-0.0072529	0.0390157	0.8525252
Simple mode	23	-0.0356433	0.1001985	0.7254335
Weighted mode	23	-0.0112945	0.0710764	0.8751923

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.72580	21	0.7848540
Inverse variance weighted	16.48917	22	0.7908891

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049298	0.0056423	0.3921575

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005007	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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