Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1004)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0975909	0.0998201	0.3393681
Weighted median	23	0.0626672	0.0547643	0.2524956
Inverse variance weighted	23	0.0201846	0.0390154	0.6049127
Simple mode	23	-0.1539018	0.1100291	0.1758315
Weighted mode	23	0.0964645	0.0653990	0.1543772

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.66601	21	0.7881131
Inverse variance weighted	16.37578	22	0.7968082

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047535	0.0056423	0.4090148

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005044	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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