Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1003)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0997740	0.1059855	0.3572075
Weighted median	23	-0.0902508	0.0566618	0.1112052
Inverse variance weighted	23	-0.0333846	0.0409167	0.4145476
Simple mode	23	-0.0986369	0.0845114	0.2556478
Weighted mode	23	-0.0986369	0.0634338	0.1342254

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.67419	21	0.3091113
Inverse variance weighted	24.19630	22	0.3370247

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004077	0.0059908	0.5035994

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007554	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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