Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1002)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0398525	0.1055878	0.7096383
Weighted median	23	0.0490755	0.0612881	0.4232849
Inverse variance weighted	23	0.0382039	0.0409355	0.3506803
Simple mode	23	0.0637678	0.1135912	0.5802130
Weighted mode	23	0.0668550	0.0852415	0.4412271

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.49710	21	0.3180574
Inverse variance weighted	24.21884	22	0.3358636

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047934	0.0059683	0.4308882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000763	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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