Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1001)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2626054	0.0998169	0.0156212
Weighted median	23	-0.0361374	0.0583726	0.5358619
Inverse variance weighted	23	-0.0587759	0.0390148	0.1319384
Simple mode	23	-0.0165422	0.1006164	0.8709103
Weighted mode	23	-0.0392358	0.0918280	0.6733319

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.87823	21	0.8747727
Inverse variance weighted	18.80006	22	0.6576402

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0125174	0.0056422	0.0376743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006384	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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