Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 100)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0022224	0.1005706	0.9825789
Weighted median	23	0.0638889	0.0600638	0.2874720
Inverse variance weighted	23	0.0105353	0.0390157	0.7871384
Simple mode	23	0.0933722	0.1047085	0.3821850
Weighted mode	23	0.0983556	0.0727971	0.1903981

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.31714	21	0.4397282
Inverse variance weighted	21.33642	22	0.5000382

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007835	0.0056848	0.8916983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006488	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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