Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 10)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0048476	0.0998196	0.9617258
Weighted median	23	-0.0492380	0.0577511	0.3938868
Inverse variance weighted	23	-0.0020615	0.0390154	0.9578609
Simple mode	23	-0.0707864	0.1094378	0.5244407
Weighted mode	23	-0.0814517	0.0813724	0.3277226

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.07366	21	0.5166000
Inverse variance weighted	20.07458	22	0.5783747

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001711	0.0056423	0.9760951

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006084	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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