Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0060928	0.1130490	0.9575282
Weighted median	23	0.0219399	0.0606452	0.7175203
Inverse variance weighted	23	-0.0142560	0.0432099	0.7414576
Simple mode	23	-0.0040006	0.1200858	0.9737243
Weighted mode	23	0.0360047	0.0880127	0.6864323

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.93603	21	0.1729808
Inverse variance weighted	26.98508	22	0.2117938

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012496	0.0063901	0.8468374

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008217	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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