Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 9)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0056996	0.1235378	0.9636375
Weighted median	23	-0.0569457	0.0575636	0.3225333
Inverse variance weighted	23	-0.0434667	0.0472991	0.3581084
Simple mode	23	-0.1114841	0.1073307	0.3102274
Weighted mode	23	-0.0396212	0.0624085	0.5320621

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.16494	21	0.0563365
Inverse variance weighted	32.33390	22	0.0718789

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023193	0.0069829	0.7430804

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010174	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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