Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 8)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1282337	0.1034151	0.2286565
Weighted median	23	-0.0908738	0.0575138	0.1140989
Inverse variance weighted	23	-0.0494082	0.0401312	0.2182605
Simple mode	23	0.1617062	0.1211845	0.1957270
Weighted mode	23	-0.1310321	0.0799179	0.1153142

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.54059	21	0.3689530
Inverse variance weighted	23.27665	22	0.3862517

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048407	0.0058456	0.4169263

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007539	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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