Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 7)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0412890	0.0998205	0.6833373
Weighted median	23	0.0449403	0.0578974	0.4376279
Inverse variance weighted	23	-0.0150493	0.0390157	0.6997008
Simple mode	23	0.0232964	0.1073209	0.8301525
Weighted mode	23	0.0404244	0.0759960	0.6001066

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.91454	21	0.4641738
Inverse variance weighted	21.29052	22	0.5028506

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034597	0.0056423	0.5463463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006497	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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