Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 6)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0282599	0.0998203	0.7798666
Weighted median	23	0.0447653	0.0567338	0.4300879
Inverse variance weighted	23	0.0126615	0.0390156	0.7455407
Simple mode	23	0.0417525	0.0952832	0.6655184
Weighted mode	23	0.0473238	0.0554524	0.4026267

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.43818	21	0.6211316
Inverse variance weighted	18.63654	22	0.6676518

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002513	0.0056423	0.6606024

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005679	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8