Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 5)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0493866	0.0998202	0.6259090
Weighted median	23	0.0051552	0.0553197	0.9257534
Inverse variance weighted	23	-0.0099512	0.0390158	0.7986808
Simple mode	23	0.0117655	0.0945607	0.9021107
Weighted mode	23	0.0192527	0.0723282	0.7925757

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.81915	21	0.8772414
Inverse variance weighted	14.23624	22	0.8928830

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036439	0.0056423	0.5253895

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004334	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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