Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 4)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1563955	0.1187012	0.2018466
Weighted median	23	-0.0859375	0.0595286	0.1488415
Inverse variance weighted	23	-0.1007294	0.0456081	0.0272033
Simple mode	23	-0.0347406	0.1210557	0.7768129
Weighted mode	23	-0.1937393	0.0845941	0.0319621

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.69729	21	0.0982418
Inverse variance weighted	30.06438	22	0.1169080

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034185	0.0067097	0.6157214

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011129	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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