Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 3)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0217342	0.0998205	0.8297392
Weighted median	23	-0.0116099	0.0556696	0.8347994
Inverse variance weighted	23	0.0308534	0.0390156	0.4290630
Simple mode	23	-0.1107276	0.0878105	0.2205235
Weighted mode	23	0.0026405	0.0716812	0.9709471

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.45983	21	0.8916661
Inverse variance weighted	13.78741	22	0.9088521

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032294	0.0056423	0.5731615

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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