Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 21)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0061946	0.1015734	0.9519466
Weighted median	23	0.0495485	0.0536679	0.3558804
Inverse variance weighted	23	0.0473842	0.0390899	0.2254412
Simple mode	23	0.0130939	0.0877496	0.8827401
Weighted mode	23	0.0415572	0.0697712	0.5575069

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.74384	21	0.4143978
Inverse variance weighted	22.08389	22	0.4548909

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032903	0.0057414	0.5726794

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007139	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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