Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 20)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2171549	0.1354575	0.1238433
Weighted median	23	-0.1092913	0.0601838	0.0693766
Inverse variance weighted	23	-0.0579733	0.0536977	0.2803092
Simple mode	23	-0.1218543	0.0979695	0.2266643
Weighted mode	23	-0.1438299	0.0655938	0.0391927

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.67350	21	0.0107344
Inverse variance weighted	41.67524	22	0.0068416

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0097755	0.0076568	0.2156454

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013296	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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