Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 2)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0225095	0.0998202	0.8237702
Weighted median	23	-0.0563257	0.0563712	0.3177015
Inverse variance weighted	23	-0.0554652	0.0390155	0.1551362
Simple mode	23	-0.0838775	0.1032161	0.4251316
Weighted mode	23	-0.0657806	0.0624212	0.3034030

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.68433	21	0.4783614
Inverse variance weighted	20.81298	22	0.5323205

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020238	0.0056423	0.7234122

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006919	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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