Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 19)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1849115	0.0998193	0.0780683
Weighted median	23	-0.1020373	0.0542268	0.0598801
Inverse variance weighted	23	-0.0773085	0.0390151	0.0475353
Simple mode	23	-0.0683184	0.0968283	0.4878649
Weighted mode	23	-0.1375810	0.0599977	0.0317683

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.89203	21	0.7176303
Inverse variance weighted	18.26360	22	0.6902503

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066079	0.0056423	0.2546599

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006724	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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