Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 18)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0326969	0.1152767	0.7794653
Weighted median	23	0.1012512	0.0613640	0.0989406
Inverse variance weighted	23	0.0308272	0.0440212	0.4837522
Simple mode	23	0.1147330	0.0970661	0.2498212
Weighted mode	23	0.1224914	0.0887451	0.1813717

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.00746	21	0.1399399
Inverse variance weighted	28.00787	22	0.1754204

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001148	0.006516	0.9861077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008676	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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