Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 17)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2268074	0.1078586	0.0477160
Weighted median	23	-0.0452309	0.0631537	0.4738654
Inverse variance weighted	23	-0.0558181	0.0440018	0.2046049
Simple mode	23	0.0802214	0.1369383	0.5639575
Weighted mode	23	0.1347733	0.1494428	0.3769102

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.52091	21	0.2685092
Inverse variance weighted	27.98466	22	0.1761902

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0105008	0.0060969	0.0997085

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009099	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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