Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 16)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1687880	0.0998195	0.1056396
Weighted median	23	0.1186418	0.0573560	0.0385916
Inverse variance weighted	23	0.0658722	0.0390153	0.0913403
Simple mode	23	0.0813225	0.0974305	0.4128752
Weighted mode	23	0.1174749	0.0625443	0.0736625

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.46373	21	0.6194991
Inverse variance weighted	19.71840	22	0.6006493

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063201	0.0056423	0.2753091

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006839	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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