Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 15)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2422227	0.1211342	0.0586436
Weighted median	23	-0.0835279	0.0632235	0.1864502
Inverse variance weighted	23	-0.0741758	0.0486961	0.1276988
Simple mode	23	-0.0776464	0.1140659	0.5031541
Weighted mode	23	-0.0558193	0.0992076	0.5793613

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.92843	21	0.0748573
Inverse variance weighted	34.27398	22	0.0460611

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.01032	0.0068472	0.1466618

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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