Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 14)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0065659	0.0998209	0.9481777
Weighted median	23	-0.0043905	0.0534462	0.9345294
Inverse variance weighted	23	-0.0282765	0.0390156	0.4686066
Simple mode	23	-0.0024497	0.0813373	0.9762444
Weighted mode	23	0.0081418	0.0596784	0.8927237

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.00259	21	0.8228220
Inverse variance weighted	15.14639	22	0.8558794

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021397	0.0056424	0.7083359

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004749	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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