Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 13)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0436306	0.1019096	0.6729150
Weighted median	23	0.0501451	0.0573721	0.3821005
Inverse variance weighted	23	0.0240562	0.0393961	0.5414486
Simple mode	23	0.0845213	0.0980418	0.3979358
Weighted mode	23	0.0523988	0.0705407	0.4654516

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.88865	21	0.4059508
Inverse variance weighted	22.43137	22	0.4344074

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041566	0.0057604	0.4785064

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006912	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8