Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 12)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1530348	0.1039314	0.1557268
Weighted median	23	-0.0730328	0.0550382	0.1845259
Inverse variance weighted	23	-0.0045918	0.0419021	0.9127385
Simple mode	23	0.0124952	0.0991711	0.9008790
Weighted mode	23	-0.0510047	0.0624629	0.4229342

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.76553	21	0.3566060
Inverse variance weighted	25.37579	22	0.2794439

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0091159	0.0058747	0.1356712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007693	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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