Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 11)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0327402	0.0998205	0.7461668
Weighted median	23	0.0471899	0.0566010	0.4044337
Inverse variance weighted	23	0.0873394	0.0390156	0.0251834
Simple mode	23	0.0571934	0.0890990	0.5275651
Weighted mode	23	0.0606051	0.0592573	0.3175441

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.85283	21	0.4679632
Inverse variance weighted	21.20595	22	0.5080428

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033529	0.0056423	0.5586963

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007944	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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