Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 10)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0149656	0.0998205	0.8822545
Weighted median	23	0.0490132	0.0543106	0.3668119
Inverse variance weighted	23	-0.0067667	0.0390156	0.8623090
Simple mode	23	-0.1513437	0.0966635	0.1316963
Weighted mode	23	0.0403212	0.0689063	0.5643943

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.95728	21	0.8250895
Inverse variance weighted	14.96524	22	0.8637254

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005035	0.0056423	0.9297408

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004544	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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