Two sample MR report

Telomere_length against rfMRI amplitudes (ICA25 node 1)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0500838	0.0998203	0.6210703
Weighted median	23	-0.0000381	0.0593220	0.9994873
Inverse variance weighted	23	0.0214041	0.0390154	0.5832765
Simple mode	23	0.0659570	0.1112794	0.5594160
Weighted mode	23	0.0400887	0.0760505	0.6033768

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.93293	21	0.6532446
Inverse variance weighted	18.03036	22	0.7041866

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017612	0.0056424	0.758009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005555	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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