Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 9)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0584485	0.0998209	0.5644289
Weighted median	23	-0.0264668	0.0551117	0.6310565
Inverse variance weighted	23	-0.0199414	0.0390156	0.6092718
Simple mode	23	-0.0430907	0.0862005	0.6221160
Weighted mode	23	-0.0430907	0.0629180	0.5005779

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.26458	21	0.5045622
Inverse variance weighted	20.44023	22	0.5555233

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023647	0.0056423	0.6793983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006273	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8