Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 8)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2362197	0.1235323	0.0695881
Weighted median	23	-0.0498564	0.0618436	0.4201453
Inverse variance weighted	23	-0.0200408	0.0510723	0.6947622
Simple mode	23	0.1031404	0.1433651	0.4794527
Weighted mode	23	-0.1811656	0.0848311	0.0440919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.16395	21	0.0563497
Inverse variance weighted	37.70018	22	0.0197924

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0132757	0.0069827	0.0710844

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011503	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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