Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 7)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0042952	0.1082908	0.9687362
Weighted median	23	-0.0123440	0.0548620	0.8219791
Inverse variance weighted	23	0.0083073	0.0413546	0.8407920
Simple mode	23	-0.0408143	0.0896046	0.6532181
Weighted mode	23	-0.0105560	0.0582810	0.8579299

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.71513	21	0.2597127
Inverse variance weighted	24.71704	22	0.3107968

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002464	0.0061211	0.9682724

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007503	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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