Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 6)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0483135	0.0998204	0.6333920
Weighted median	23	0.0816520	0.0542315	0.1321648
Inverse variance weighted	23	0.0786594	0.0390155	0.0437890
Simple mode	23	0.0330742	0.0861169	0.7046199
Weighted mode	23	0.0751134	0.0643970	0.2559375

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.92917	21	0.5896841
Inverse variance weighted	19.03825	22	0.6429653

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018635	0.0056423	0.7444619

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007001	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8