Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 55)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0508131	0.1055929	0.6353382
Weighted median	23	-0.0177091	0.0550099	0.7475082
Inverse variance weighted	23	-0.0148211	0.0407583	0.7161313
Simple mode	23	0.0497472	0.0953197	0.6069563
Weighted mode	23	0.0125116	0.0637061	0.8461033

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.49889	21	0.3179661
Inverse variance weighted	24.00918	22	0.3467483

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040306	0.0059686	0.5068551

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007319	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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