Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 54)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1736109	0.0998197	0.0966311
Weighted median	23	-0.1075609	0.0538389	0.0457354
Inverse variance weighted	23	-0.0641051	0.0390153	0.1003672
Simple mode	23	0.0594111	0.0823071	0.4780066
Weighted mode	23	-0.1034944	0.0584432	0.0904411

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.68145	21	0.7302260
Inverse variance weighted	18.10194	22	0.6999272

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067248	0.0056423	0.2466174

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006303	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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