Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 53)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0564097	0.1125903	0.6215699
Weighted median	23	-0.0056884	0.0541632	0.9163568
Inverse variance weighted	23	0.0079031	0.0433874	0.8554628
Simple mode	23	0.0046648	0.0883684	0.9583772
Weighted mode	23	-0.0130546	0.0594911	0.8283315

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.71638	21	0.1804392
Inverse variance weighted	27.20633	22	0.2034944

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039494	0.0063641	0.5415549

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008257	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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