Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 52)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1177427	0.1396149	0.4085423
Weighted median	23	-0.1124079	0.0679687	0.0981647
Inverse variance weighted	23	-0.0779284	0.0534368	0.1447499
Simple mode	23	-0.2168563	0.1215076	0.0881055
Weighted mode	23	-0.2025581	0.0974460	0.0495167

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.08359	21	0.0054751
Inverse variance weighted	41.27137	22	0.0076492

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002445	0.0078918	0.7597522

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013714	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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