Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 51)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0181309	0.0998211	0.8576118
Weighted median	23	-0.0227773	0.0553821	0.6808699
Inverse variance weighted	23	-0.0348622	0.0390157	0.3715658
Simple mode	23	-0.0048505	0.0930333	0.9588895
Weighted mode	23	-0.0077336	0.0599293	0.8984938

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.29647	21	0.7527689
Inverse variance weighted	16.32963	22	0.7991960

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010275	0.0056424	0.8572517

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000519	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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