Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 50)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1030396	0.0998189	0.3136903
Weighted median	23	-0.0682917	0.0605123	0.2590842
Inverse variance weighted	23	-0.0699530	0.0390151	0.0729772
Simple mode	23	-0.0581438	0.0998876	0.5664224
Weighted mode	23	-0.0460536	0.0882350	0.6069261

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.81730	21	0.8773184
Inverse variance weighted	13.94698	22	0.9033503

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020319	0.0056423	0.7223591

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00052	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8