Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 5)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0697715	0.1217539	0.5726944
Weighted median	23	0.1635730	0.0620923	0.0084298
Inverse variance weighted	23	0.0812475	0.0465062	0.0806329
Simple mode	23	0.0978271	0.1188630	0.4193265
Weighted mode	23	0.1501638	0.0788828	0.0701220

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.24403	21	0.0696914
Inverse variance weighted	31.25963	22	0.0909239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007047	0.0068821	0.9194091

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010786	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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