Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 49)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0052288 0.1056817 0.9610065
Weighted median 23 -0.0846828 0.0624226 0.1749071
Inverse variance weighted 23 -0.0256861 0.0403995 0.5249055
Simple mode 23 -0.1372666 0.1025145 0.1942436
Weighted mode 23 -0.1298783 0.1096872 0.2490178

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.53958 21 0.3158972
Inverse variance weighted 23.58916 22 0.3691272

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0012563 0.0059737 0.8354578

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007279 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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