Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 48)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1698691	0.1083597	0.1319108
Weighted median	23	-0.0450263	0.0588258	0.4440225
Inverse variance weighted	23	-0.0057760	0.0439654	0.8954780
Simple mode	23	0.1504463	0.1113905	0.1905471
Weighted mode	23	-0.0585122	0.0670013	0.3919330

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.74677	21	0.2582983
Inverse variance weighted	27.93642	22	0.1777980

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0100769	0.006125	0.1148129

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008472	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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