Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 47)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0930554	0.1280813	0.4755330
Weighted median	23	0.0324958	0.0545532	0.5513945
Inverse variance weighted	23	0.0305346	0.0492374	0.5351591
Simple mode	23	0.0319935	0.0895935	0.7244222
Weighted mode	23	0.0275036	0.0609845	0.6564076

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.57486	21	0.0314196
Inverse variance weighted	35.03790	22	0.0383933

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038393	0.0072397	0.601453

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010802	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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