Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 46)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1185936	0.1162463	0.3192472
Weighted median	23	-0.0591238	0.0571329	0.3007403
Inverse variance weighted	23	-0.0213167	0.0452561	0.6376240
Simple mode	23	0.0455919	0.0911480	0.6219033
Weighted mode	23	-0.0299008	0.0656192	0.6530925

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.47980	21	0.1270609
Inverse variance weighted	29.60072	22	0.1284961

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059738	0.0065708	0.3735941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000906	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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