Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 45)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2430994	0.1173039	0.0507309
Weighted median	23	-0.0089750	0.0568721	0.8746068
Inverse variance weighted	23	0.0047184	0.0500996	0.9249660
Simple mode	23	0.0536214	0.1050557	0.6148480
Weighted mode	23	-0.0299384	0.0629107	0.6388465

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.00099	21	0.1139777
Inverse variance weighted	36.27598	22	0.0283608

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0152184	0.0066306	0.0321239

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010996	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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