Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 44)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0039446	0.1181667	0.9736857
Weighted median	23	0.0602679	0.0574291	0.2939794
Inverse variance weighted	23	-0.0267676	0.0452102	0.5538042
Simple mode	23	0.0419773	0.1068929	0.6983168
Weighted mode	23	0.0495491	0.0757908	0.5200406

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.42900	21	0.1040770
Inverse variance weighted	29.54074	22	0.1300606

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001886	0.0066793	0.7804262

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009094	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8