Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 43)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1644263	0.1107623	0.1525333
Weighted median	23	-0.0185290	0.0590576	0.7537154
Inverse variance weighted	23	-0.0334609	0.0439276	0.4462224
Simple mode	23	-0.0595467	0.1171483	0.6163009
Weighted mode	23	-0.0819749	0.0957386	0.4010974

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.85714	21	0.2119489
Inverse variance weighted	27.88898	22	0.1793898

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080427	0.0062609	0.2129258

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008674	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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