Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 41)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1023794	0.0998190	0.3167268
Weighted median	23	-0.1202112	0.0552641	0.0296141
Inverse variance weighted	23	-0.0938095	0.0390151	0.0161972
Simple mode	23	-0.0425666	0.1074385	0.6957780
Weighted mode	23	-0.1783349	0.0813901	0.0393248

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.61918	21	0.8853948
Inverse variance weighted	13.62788	22	0.9141587

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005263	0.0056423	0.92657

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005882	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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