Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 40)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0829795	0.1047386	0.4370720
Weighted median	23	0.0018300	0.0562548	0.9740489
Inverse variance weighted	23	0.0107680	0.0408873	0.7922741
Simple mode	23	0.0719444	0.1123831	0.5286727
Weighted mode	23	-0.0236363	0.0667764	0.7267368

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.12036	21	0.3375949
Inverse variance weighted	24.16143	22	0.3388249

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005757	0.0059203	0.3419117

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007345	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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