Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 4)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0219370	0.1005590	0.8294174
Weighted median	23	-0.0431128	0.0579517	0.4569111
Inverse variance weighted	23	-0.0418623	0.0390157	0.2832899
Simple mode	23	-0.0397426	0.1046401	0.7077334
Weighted mode	23	-0.0315525	0.0673996	0.6442892

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.31189	21	0.4400438
Inverse variance weighted	21.79405	22	0.4722375

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039179	0.0056841	0.4981942

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006953	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8